Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma
نویسندگان
چکیده
منابع مشابه
Discovery of a Potent, Covalent BTK Inhibitor for B-Cell Lymphoma
BTK is a member of the TEC family of non-receptor tyrosine kinases whose deregulation has been implicated in a variety of B-cell-related diseases. We have used structure-based drug design in conjunction with kinome profiling and cellular assays to develop a potent, selective, and irreversible BTK kinase inhibitor, QL47, which covalently modifies Cys481. QL47 inhibits BTK kinase activity with an...
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ژورنال
عنوان ژورنال: ACS Chemical Biology
سال: 2014
ISSN: 1554-8929,1554-8937
DOI: 10.1021/cb4008524